Tissue samples were taken from the lesion and from right and left colon for comparison with a HNPCC database of more than 400 genes identified with the syndrome (see colon cancer discussion.) Defective genes for repair of damaged DNA may be one mechanism operating in the syndrome. There has also been a difference in the genes associated with right and left colon carcinomas. The lesions in HNPCC are most commonly on the right.
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